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J Mol Biol 430 (21):3942-3953

Guenther, N.D

In native biological models, complex structural injuries and chronic inflammatory states engage multiple, overlapping cellular networks

thus, mitochondrial dysfunction may also be involved (Kerckhove et al., 2012) have reported in rat sciatic nerve how bortemozib, as other antitumor drugs, causes significant deficits in complex I and II of ETC, as well as in ATP production, at two time points (pain onset -day 7- and peak pain -day 35-)